Propanoic acid to 2-chloropropanoic acid is the goal

propanoic acid to 2-chloropropanoic acid is the goal.

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hindawi.com/journals/jchem/2017/1307541/
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can you control the heat finely enough so that it doesn't decompose on you?

PhD organic chemist here, what the fuck do you want? mechanisms?

Bumping for interest.

hindawi.com/journals/jchem/2017/1307541/
its based on this thing.

That's an unregulated neurotoxin. What are your plans, OP?

This doesn't look like dope... why?

>Mechanism of Chlorination Process: From Propanoic Acid to α-Chloropropanoic Acid and Byproducts Using Propanoic Anhydride as Catalyst

apparently any acid anhydride can be used,

yes, but what exactly do you want to know?

why what ?

there is no reference about the yield of each product,
i mean it could be something like 1% of 2-chloropropanoic acid and 99% of 1-chloropropanoic acid

or any other ratio.

also using sulfuryl chloride seem to be more specific for that chlorination.

unfortunately in the exemple it not an organic acid, its a ketone,

i was thinking instead.
make lot of thionyl chloride.
and chlorinate lactic acid.

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Organic chemist PhD here again. I would instead use thionyl chloride to chlorinate lactic acid. The yield would be quite high (i'd estimate 90-95%) of the alpha-chloropropionic acid you want. The alcohol group should readily attack the sulfur and everything should continue smoothly.

Do you have any ClF3?

wtf do you want me to do with chlorine trifluoride ?
jeez that shit is corrosive as fuck.

What about the Hell-Volhard-Zelinsky reaction? Though I think it may still result in a 50/50 split between the 3-bromo and 2-bromo molecules.

how do i get high off of it?

yeah even using thionyl chloride is easier to make than phosphorus tribromide.

What are you trying to make?

Do you absolutely have to start with propanoic acid?

no
i can start with other stuff.if it make it easier.
i tought of propanoic acid because its easy to buy in 10 Liter or more quantity.

meanwhile so this thread stay alive,

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kek, nothing, just we used to install gas cabinets for ClF3 and the city officials never allowed the customer to use them.

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I think the enolate in this situation will always screw you over. There's like probably a hundred reactions you could do, but they'll always split between the 3 and 2-halo's.

If I remember my organic chemistry right, which I probably don't, doing something like this should work. Either that or this is just vaguely remembered bs lol

well if i can chlorinate propanoic acid simply.
i would separate the 2 and 3 with distillation and find a use the both of them. even if i get one that is not on the good position there is alway an use for it.

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