>no humans so they can look out for themselves
that defeats the plot of mutancy being an oppressed minority, user. it's self defeating.
>make the X-Men series interesting again
brink back Dark Beast and/or start a series that goes through Dark Beast and Emma's past with the Morlocks, include Morbius and any other characters that were underground or couldn't be a part of society
616 beast should go to mojo world and and explore why he could do concussive blasts like that one time he went there with cannonball and a vietnamese mutant i've never heard of (Beast #1-3). he should take a break from the x-men and do his own thing for a while.
Psylocke should get her own comic, featuring HYDRA (villain), Daredevil, Beast, Spiral (villain), Shadow King (villain), Mystique, Dr. Strange, Dracula (villain), Sinister, Purifiers, Jubilee, Illyana and Nightcrawler. any psionic characters would be a good addition, like Cable, X-Man, or badasses like Bishop or his sister Shard and perhaps Gateway
if you want to do stuff with deep space, involve Galactus's herald Stardust, Anihilus cronies, Thanos, the Shiar and a war between Phalanx and the Brood
most importantly, mutants should be pairing off and having mutant kids. Marvel has not depicted this for the most part. once parents' children is in danger, they'll be more radicalized and conflicts will be avoided, but when they happen, will escalate quickly.