New Non-addictive Opiate!

arstechnica.com/science/2016/09/new-opioid-douses-pain-without-being-addictive-or-deadly-in-primates/

Would you take it? Are opiates ever going to be safe?

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>Would you take it?
I'd take it even if it was addictive and unsafe

>arstechnica.com
Are you daf

Good luck in the future with your burnt out endorphin receptors.

as a pain killer? no, moprhine is good enough. for recreational use? no, alcohol and cannabis are good enough.

According to a report in the Proceedings of the National Academy of Sciences, an opioid drug referred to as BU08028 was able to alleviate pain in a dozen monkeys just as well as other opioid painkillers, such as morphine. Yet, unlike every other opioid drug, BU08028 showed no signs of being addictive. Even at high dose—at which other opioid drugs inhibit the respiratory and cardiovascular system, which can be fatal—BU08028 was harmless.

"Based on our research, this compound has almost zero abuse potential and provides safe and effective pain relief," Mei-Chuan Ko, a professor of physiology and pharmacology at Wake Forest Baptist Medical Center and lead author of the study, said in a statement. "This is a breakthrough for opioid medicinal chemistry that we hope in the future will translate into new and safer, non-addictive pain medications."

In pain experiments, which involved dipping monkeys' tails into hot water, BU08028 was a potent pain-killer. A single dose relieved pain for up to 30 hours. Next, in experiments in which the monkeys were trained to self-medicate, BU08028 proved no more habit-forming than a control dose of saline. Scientists forced one group of monkeys to take BU08028, while another group was forced to take morphine. When the drugs were taken away, the monkeys who had taken BU08028 showed no withdrawal symptoms, unlike the monkeys who had blazed on morphine.

don't live in a perpetual state of pain, and if I did, I'd an her0 before becoming a drug cuck

They're banning Kratom at the end of the month

Fucking fascists man, i dont even take kratom anymore, but its a crime against those people on heroin to take away something that could help them with their addiction.

This. You simply can't get that good feeling without it being addictive. It may not be addictive in the same way as other things, but you're acclimating your body to associate 'feeling good' with the presence of a drug - and conversely, absence of the drug feels pretty fucking bad.

There's no feel-good drug where you don't have to pay the piper eventually.

oh wait, apparently it's a painkiller without a good feeling associated with it. Nevermind. I'd take it, since it'd do nothing but make me feel less pain.

I hope this comes out soon and cheap. I want to get off Percocets for my blown disks in my back. I fucking hate the pills but they make it so I can get up in the morning and work. That other stuff, if true and if it works the same on humans, sounds very interesting.

>opioid
>non addictive

Unless it kills pain without any euphoria it'll at the very least be psychologically addictive.

It'd be nice if it didn't suppress breathing though so at least it didn't kill people.

says in the article that it doesn't suppress breathing

Well I guess that explains why they are banning Kratom.

yeah and that part is nice. If it truly kills pain for 30 hours on a single dose and even if it is addictive the long half life will lower its addiction potential substantially (the reason why Methadone is used for weaning off opioid addiction is because of its long halflife) and it'll be good for medical uses and will basically eliminate the market for Methadone, MS contin, Oxycontin, and Zohydro ER. unless it has other side effects like itching (like for me, I can't take oxycodone, it makes me itch, and MS contin makes my stomach upset, so I take Zohydro ER which is Hydrocodone (Norco/Vicodin/Lortab) in a 12 hour extended release.

There will still be a market for shorter acting opioids like immediate release oxycodone and hydrocodone and IV Morphine for emergencies, and Fentanyl for cancer patients I think...

But this would go a long way for chronic pain sufferers if it truly works for that long and without the breathing suppression and lower addiction potential.

What is Zohydro like? What do I have to have wrong with me to get that shit? Vicodin that lasts all day sounds like a dream.

it's exactly why they're banning Kratom.

Which I think that ban is bullshit. Schedule I is a graveyard for potentially useful medications. Once something goes schedule I it never comes back and they don't even allow research on it unless it's research supporting the DEA's narrative that this is a deadly poison that humans should never use.

Pain removal is a meme. It just distracts you from the pain with pleasure

It's absolutely insane that they're banning kratom. It's not dangerous, but it is addictive. Every once in a while, some retard takes too much and thinks he's dying, then goes to the hospital.

They used the number of people showing up at the hospital as an indicator of it's inherent danger. But none of those people actually needed to go, they just went because they didn't understand what drug they're using.

Kratom was a big part of my life until I decided to kick it. It wasn't too hard to stop, and I can now enjoy it responsibly from time to time. Well, not anymore I suppose.

It's a fucking travesty.

Right now, at that very moment, my answer would be yes. I'm fucking depressed and I need something to ease my mind.

Well also its a natural product so they can't make any money off of it. Same reason weed is banned.

... it's vicodin without the tylenol (though you can add tylenol to it on your own) that lasts for 12 hours instead of 5-6. I don't take high doses, I don't really like being "high" on opioids since it just makes me have to sleep after an hour or two of feeling good.

As for "something wrong with you" yeah you need a chronic pain condition that requires long term pain management, and I mean pain that makes you want to shoot yourself every day if you don't get relief.

I have 2 autoimmune diseases that are destroying my joints. It causes a shitload of inflammation and pain, especially at night. I was on just Vicodin, just a low dose so that It took the edge off so that I could sleep, but I'd wake up after about 5 hours still in pain and have to limp over screaming to take more.

So we switched to the 12 hour so that I could get a full night's sleep (sleeplessness actually makes the inflammation worse afterall)

It's not worth it just for a high, I'd trade being healthy and able to walk without difficulty and be able to work for all the drugs in the world.

It's linked to 15 deaths I think, but it's not the cause, rather present in the system of a junkie that OD on a bunch of shit. That, and hospital visits is why they are banning it.

Pretty weak excuse, considering how many people die every year from actual opioids and alcohol.

FUCK them for banning kratom. I hope the AKA sues their ass.

It's over bro, they won't beat DEA

I wanted to post an SMBC where they invent a cure for addiction and peope get addicted to it.
but I can't find said comic.

My sister has an autoimmune disease that destroys her joints and she takes a biologic (Enbrel). Why do you need opiates?

No, but I hope they can delay the ban going into effect until January 1. I don't know what I'm gonna do. Stocking up while I can.

Start tampering to get off it.

I'm literally numbing myself with drinks to stave off the depression and loneliness I feel everyday of my life.

I could probably lose some weight and be social if I started using opioids.

30, super fat, divorced, no kids, family is bunch of shitty people that just want to use me, the only I have going for me is I make like 150k/yr

No, opioids really do suppress some of the perception of pain. They're stronger at it than any OTC, but they also cause euphoria so any pain left over that you still feel is just less alarming.

Like when I take opioids and sleep, I can still feel some pain, but my brain says "this isn't as big of a deal, I can ignore this" and sleep, where if I'm on just OTC meds like ibuprofen and tylenol (simultaneously of course) my brain is like "WAKE UP YOU IDIOT, YOU'RE IN PAIN!" and won't let me sleep.

But even though I still feel some pain in the background, it is LESS pain than I would feel otherwise.

Already have. Down from 14g/day to 10g now down to 7. These numbers are likely lower, as I'm counting via size 00 capsules and I'm not stuffing them enough to say theirs 0.5g in each.

m8 if I made that much money I feel like nothing would ever get me down sheeit.

Since your fat and live alone do you at least get fat on premium beef, caviar, expensive fish cuts, and fancy cheese.

because we're currently trying to find the right biologic. So far the ones I've taken have been ineffective or I've made antibodies against them.

Yep, start tapering now. Stop getting high from it, and only use as much as you need to feel okay. If you do this for two or three weeks, by the time you're ready to go cold turkey you'll have forgotten what feeling high is like.

It took me a few weeks of tapering to get ready for the leap. I did, and I'm happy I did it. You will be too, eventually. It might take two months to feel normal again. Just a heads up.

lose all your weight
take hrt and become a girl

I think you just want an excuse to take dope.

Just kill yourself now so I can live your life and make it 10x better

Why not sack the fuck up and cease ingestion when drug is not required.

Well the bummer is that I take it for anxiety and depression, so feeling normal is not an enticing prospect. Still plan on getting off it entirely though. Gonna start looking into Kava kava extract for my anxiety. I'm not going on the prescription jew ever again.

Akuamma is the new replacement that may or may not be better than kratom but it is similar from what I have gathered. The whole DEA bit is a stupid fucking game of whack-a-mole and often the replacements that crop up that are still legal are far far worse- see fentanyl analogues.


>A fucking tree

Current Kratom user here. Got me off of Dilaudid. Used other opiates of course but it was mostly that. Very unhappy with the new scheduling. Attempting to wean myself off now.

did it work for you ;)

yeah mane

Good luck man, we can do it!

are the lebs pleased with your performance?

Sounds like another bluepill. We need more pain, not less FUCK

You know when they're evaluating DMARDs they put you on them for about 3-6 months right?

You don't just take 1 dose and say "that didn't work, put me on a different one".

It can take several weeks to notice any benefit at all.

Also, the VA is cheap. They want to start you out on just NSAIDs until it's clear that's not going to work. Then they put you on Methotrexate for 6 months, then maybe, maybe your rheumatologist will see that you're still regularly bleeding from lesions in your face and scalp and then maybe they'll try a biologic. Then they'll give you something that is prescribed WITH methotrexate, starting with Humira for me at least. Then when that didn't work. I was on Remicade for a few doses until labs showed I developed antibodies to it...

Next appointment is in late october.

So meanwhile while you're evaluating treatment, they still have to manage pain.

no lebs in qld

I know myself.

I would get mentally addicted way too fast to use this.

And i actually could use it with the shit tier body i have.

Thanks. Really pissed though. Opiates are the only recreational drug I even really enjoy. Kratom gave me what I needed without having to use the real thing. I'm worried after I'm off it I'll go back to the real deal which I defiantly don't want to do.

(((They))) said the same shit about Oxy

Sister has been on Enbrel for years. They started her with NSAIDS when she was little, Methotrexate as a preteen, then Enbrel when it was invented. Not my fault you are a welfare leech.

How are people upset over the kratom ban? I drank it once and literally just threw up for hours.

It's a bupunorphine analog. It might not have the physical dependency but it will probably still lead to addiction.

huh, I took they took over. feel bad for you user, no trap should be deprived of some big brown cock :c

>Would you take it?
I would take the highly addictive morphine if I had just suffered a horrible accident and was in extreme pain.

Whoever wouldn't is a retard.

But as a drug? No fucking way mate.

got some nice white cock though

wasn't heroin meant to be nonadictive when it came out?

you absolutely suck at doing drugs
you shouldn't have even gone over 3 grams for your very first time
it was probably horrible quality to boot

forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/davidkroll/2016/08/31/dea-argues-that-public-comment-is-unnecessary-before-kratom-ban/&refURL=https://www.google.com/&referrer=https://www.google.com/

>DEA Argues That Public Comment Is Unnecessary Before Kratom Ban

>Chuck Rosenberg, acting administrator of the DEA, claims the action “is necessary to avoid an imminent hazard to the public safety.”
>(((Rosenberg)))

OY VEY GOYIM! WE DON'T NEED ANY OF YOUR commentary ON THE ISSUE! IN FACT, WE DONT NEED ANY DUE PROCESS WHATSOEVER! ITS FOR YOUR OWN GOOD GOY!!

Are we living in a legitimate alternate reality? This feels like a joke or like they are trolling. I can't believe the can happen in America. Doesn't this asshole need congress or something to do this? Sup Forums is always right

I didn't start having serious arthritis until I was 32. I'm 35 now. Prior to that, I mean I just thought I was getting old, people say you start getting regular pain waking up in your 30's and figured old injuries from when I was in the service were just coming back to haunt me. so I just took Ibuprofen and kept going to work.

But then it started getting worse, then the psoriasis started, and it started getting to where I couldn't walk, the sick days started adding up, so I lost my job. So I had to fall back on the VA. It takes them months to get you referred to a Rheumatologist. Then months to get scheduled. Got diagnosed with both Rheumatoid Arthritis and Psoriatic Arthritis at 34.

So yeah, only been working through the medication merry go round for a year.

God I love heroin.

I'm sure you need something more to fill you up tho user

I heard from one point you dont get high on it anymore?

>roach trying to score with a cute white trap
>even if it's on the other side of the world
depressing

Shit, this is the day I've been waiting for my whole life.

I abuse painkillers daily, they made me happy without the intoxication of other drugs so I could still function at work.

Been wondering when a nonaddictive opioid would be developed.

OP your post sent chills down my spine, God bless you for this find.

You build up a tolerance very quickly but this is true of pretty much all drugs. Heroin is actually quite cheap and affordable in the early stages of addiction, it's later on that it gets you when you're taking 10 times the dose you started on.

australian men are high test tho, its fine

ever since the kratom ban i've been muttering about how we need to start killing all statists. and thugs. we just need to start killing

>Non-addictive Opiate
Even if they make an opiate without physical need, psychological one still will get you.
The problem with opium is that people get so high that they only want to stay high wherever they can.

Ever consider gabapentin or pregabalin?

This as well.

I ordered a few kg of kratom from my vendor to stock up. DEA can eat shit, I've been using this stuff legally without detriment for years cycling between painkillers and kratom, I won't be stopping now lol.

This will be another example of prohibition failing.

>Would you take it? Are opiates ever going to be safe?
No and No

It's like Synthetic weed when it first came out and they claimed that it was actually better than weed and a nice alternative because you can't get into legal trouble with it

But that certainly was proven wrong pretty fast when people actually started having psychotic episodes and dying from the shit.

All drugs are bad when used for recreational purposes, some drugs are necessary for medical purposes

and you come closer to overdose point, doesnt sound very good desu
well if you think that's all you're worth then good for you kek

those are for neuropathic pain. this is actually inflammatory pain. So technically the opioids are just a stopgap until we find something that inhibits my immune system enough to not have the inflammation.

This.

Nothing better than 40 cents of tar and radio head album

The worst part of this image is that it is wrong. People everywhere think it's right because of this fucking image.

Why the shit would you slowly, ineffectively and painfully cut alongside the veins?

*daft

That sucks man. Sorry to hear that. And you know what? Lots of people say kratom has helped with joint pain.

Hope everything works out for you. Do you know if these disorders run in your family? I really wonder why so many people get autoimmune diseases now.

I'll be fine little-cock roach :)

Most overdoses are purity related, but yeah it's not a good idea. There's a reason that opiate specialists in hospitals go through years of education and training - if you don't get it right, you're going to die.

Your veins intertwine down your arms.

It's irrelevant though. Anybody who slits their wrist to suicide is retarded. People with vertical scars aren't any more "legitimate" than someone with horizontal scars.

Whats the cheapest vendor, user?

I have used kratom king for years and they have been really good. A day after the news, they marked everything on their site at a 50% discount, but now that it looks like people are stocking up they have caught on and are now going full price again. Kind of jewy, but I don't really blame them I guess. They are losing their entire business after all

>new-opioid-douses-pain-without-being-addictive-or-deadly-in-primates
Great, now when do trials outside of Chicago begin?

I only tried Kratom once because I'm not really that into opiates but I think I would remember if it were amazing or awful. I think its a shame we give the DEA so much power and not the states.

i'll stick to crack cocaine i guess
jk but i hope you find something that'll make heroin seem not needed anymore in your life man
kek, hope those unverifiable stats make you feel better bruh

>I'm not really that into opiates

>its a shame we give the DEA so much power and not the states.

I don't understand how they can just do this without any congressional approval or due process. So the DEA just has carte blanche over the citizens of the United States?

I usually hate edgy, anti-American rhetoric, but this doesn't feel very "free." They should at least have to go through a congressional oversight panel or a federal judge or something

I am just saying, I never have a problem with getting off from a white man

Why is Canadian lenght separate from the chart?

No, not that I know of.

and really, like I said, opioids are a stopgap, I hope that I can find a biologic that works well because then I can work again. Living off disability and being a NEET sucks ass.

oh, you fantasize about brown / black cock during? xd

Prevention?
Here on Spain we haven't any law against synth weed sprays for now, so youth morons are everyday in emergencies with bad trips or already death.

why would I ever?
you smelly subhumans with your tiny penises

Its not constitutional at all. They are a subdivision of the Department of Justice but basically people don't fight it because most of those who get in trouble are either poor or non-white and it rarely affects those who can afford private doctors who will usually just give you scripts for legal prescription highs instead.

hm, idk what brown people did to you but I hope soon you can recover from it m8

It's insanity that they're making it schedule one. Really no abuse potential; past like 6-7g you won't get any "higher", if the mild buzz could even be called a high. You'll just feel nauseous as shit and get double vision.

Speciosa's UEI was the real deal, though. Nobody knows exactly what the fuck it is, but it's extremely euphoric and will give you crazy withdrawals if you do it daily.

Once it's banned here no one is going to be willing to ship it. You get the death penalty for drug trafficking in Indonesia.

I'm allergic to all opiates so far
does this mean i can take a pill for my back finally instead of just being stuck with pot brownies like some kind of hippie

Just order more kratom before the ban you pussy Thats what I did