>Hank Henshaw attempted to reproduce the experiment that gave the Fantastic Four their powers, but only turns himself and his family in deformed monsters. He blames the Fantastic Four for his condition and becomes their enemy, the Super-Cyborg.
>Deathstroke is a result of a failed attempt to reproduce the Supersoldier Program in Vietnam and has a rivalry with Captain America. He also served with Frank Castle, and the two reunite years later, now on opposite sides, to fight, while reminiscing about the horrors of the war.
>Sandman and Electro join the Rogues.
>Dr. Will Magnus collaborated on Ultron's creation and Ultron regards the Metal Men as his siblings.
>Wolverine and Vandal Savage cross paths throughout History and become nemesis. Wolverine also once dueled Ra's Al Ghul and was a member of the League of Assassins.
>Batman is invited to join the Illuminati, but declines, and begins monotoring them.
>The Green Lantern Corps is meant to locate uninhabited planets for Galactus to consume and evacuate inhabited planets if he can't control his hunger, as the Guardians know he is necessary for the Universe's survival.
>The Joker has a bitter rivalry with Spider-Man, whom he considers unfunny, and becomes even madder when Spider-Man cracks so much jokes even the Joker's goons laugh at him.
>Green Arrow is a massive mutant apologist, but even they can't stand him
>Flash Thompson is a fan of The Flash.
>Plastic Man once spent a solid month trying to get Black Bolt to laugh. Black Bolt later admited he was the closest anyone got to make him break his vow of silence.
>Venom and Miraclo are both derived from the Supersoldier Serum.