> Have brain with endocannabinoid system
>Think it was evolved to get high
>Doesn't realize that endogenous signaling can't penetrate a flood of plant-based THC and CBD, which render the neural ligands anandamide and 2-AG inoperative.
>Be a drug Zombie with a self-induced partial Chemical Lobotomy.
Other urls found in this thread:
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
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ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
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jamanetwork.com
ncbi.nlm.nih.gov
journals.plos.org
pnas.org
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
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journals.plos.org
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ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
sciencedirect.com
journals.plos.org
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
nature.com
ncbi.nlm.nih.gov
monaldi-archives.org
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
nature.com
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K
>be OP
>never get invited to the party
>render the neural ligands anandamide and 2-AG inoperative.
>implying that's not the point
>implying cannabis isn't an Indo-European tradition and one of the first products of agriculture of civilization
>implying you aren't a liquor drinking nigger or a recovering pothead with no self control
>Doesn't realize that endogenous signaling can't penetrate a flood of plant-based THC and CBD, which render the neural ligands anandamide and 2-AG inoperative.
What did he mean by this?
Humans and weed obviously evolved in parallel. Moderation is key.
>which render the neural ligands anandamide and 2-AG inoperative.
assuming this is true, what are the actual concrete consequences of these neural ligands being made inoperative.
also doesn't dark chocolate activate endocannabinoid receptors? is chocolate degenerate?
> Means the brain is comprised of complex signaling subunits with feedback and feedforward control and the brains signal, being transmitted with human neurotransmitters is overpowered with a flood of THC and CBD, much like an important legal or medical conversation intended to be transmitted via shortwave can be overpowered by a Justin Bieber song transmitted by an overpowered Pirate Mexican Radio station. The information is lost.
your brain uses an endo(produced by your body) cannabinoid system to pass signals around between different parts of itself in order to regulate a bunch of stuff. when you smoke, your brain is flooded with imitator chemicals and the complex system of signals is jammed, the receptors flooded by both internal and external cannabinoids. like if you were listening to a radio and then I stood next to the radio with a jamming device so all you heard is static.
The consequences are that the human stops 'thinking' on those 'frequencies' and just wants to self-administer cannabinoids over and over again for years and years.
the brain compensates by growing new neuron
ok but what are the actual concrete consequences of this "jamming"
What kind of behavioral changes does it result in, and how does the "signal jam" lead to those behavioral consequences?
ok but what does the endocannabinoid system actually do?
You are being very vague
that metaphor is full of shit, those cycles are self healing and only people who smoke large amounts of weed daily will experience issues with this
2 Functions of the endocannabinoid system
2.1 Memory
2.1.1 Role in hippocampal neurogenesis
2.1.2 Induction of synaptic depression
2.2 Appetite
2.3 Energy balance and metabolism
2.4 Stress response
2.4.1 Exploration, social behavior, and anxiety
2.5 Immune function
2.5.1 Multiple sclerosis
2.6 Female reproduction
2.7 Autonomic nervous system
2.8 Analgesia
2.9 Thermoregulation
2.10 Sleep
A big one imo is stress response. In the beginning weed will help people with anxiety, but if they abuse it, it will end up contributing to super-anxiety
>be a jew
>spend all day spreading disinfo about marijuana because its one of the few useful drugs out there
>never make a dent in its growing acceptance and use in the international community because its dope and most people like it
>tfw you're a fucking failure on every level
That's why it's perfect.
The brain Creates the illusion of your ego
>renders anandamide and 2-AG inopperative
what the hell does this mean?
the ECS helps regulate those but it doesn't control them you pleb
if you smoke a joint every day, eat right, and exercise regularly there are next-to-no side effects
using a computer or smatphone daily has worse side effects
>Thinking you understand the immensely complex inner workings of the brain
It means that the brain will go full segwit this week when Pepe Lepen goes 60%
>Have a system
>Not overclocking or underclocking it as needed
You luddites bore me.
>>Think it was evolved to get high
Humans and weed obviously evolved in parallel. Moderation is key.
> Be drug Zombie
>Think the endocannabinoid system was evolved to get high.
> Fail to have the insight to see the ridulousness of this belief because of being a Drug Zombie.
you sound like the voice of experience, not someone who is bargaining at all. good luck.
Weed Causes Cancer:
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
Weed Reduces Volume Of Various Regions Of The Brain And Negatively Effects Motivation :
ncbi.nlm.nih.gov
Weed Is Addictive:
ncbi.nlm.nih.gov
Weed Causes Long Term Cognitive Damage:
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
jamanetwork.com
ncbi.nlm.nih.gov
journals.plos.org
pnas.org
ncbi.nlm.nih.gov
Weed Causes Depression And Anxiety Disorders:
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
journals.plos.org
journals.plos.org
Weed Causes Psychotic Disorders:
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
to all the potheads reading this: your room smells like CUM
Children of Fathers that Smoke Weed More Likely To Suffer Sudden Infant Death Syndrome:
ncbi.nlm.nih.gov
Weed Legalisation Results In More Frequent Use:
sciencedirect.com
journals.plos.org
Weed Causes Lung Damage:
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
nature.com
ncbi.nlm.nih.gov
monaldi-archives.org
Secondhand Weed Smoke Impairs Psychomotor Function And Working Memory:
ncbi.nlm.nih.gov
Weed Worsens Symptoms Of Social Anxiety Disorder:
ncbi.nlm.nih.gov
Weed Causes Deficits In Dopamine Release:
nature.com
Thats not actually the smell of weed thats literally because stoners are too lazy to clean up their jizz LOL they just jizz in their bedsheets and leave it
no it actually smells like weed
>>renders anandamide and 2-AG inopperativewhat the hell does this mean?
>renders anandamide and 2-AG inopperative
what the hell does this mean?
Means your shit doesn't work when your flooding your CNS with a bajillion times as much shatter, hash, or weed based cannabinoids as your body produces.
> Can't make simple deductions or conclusions from obvious evidence because of being drug zombie.
so being stoned makes me inebriated but I can sober up and all that returns to normal
>implying anybodies gonna read any of those articles
ncbi.nlm.nih.gov
Read this. Weed shrinks lots of different brain regions, particularly ones related to motivation.
>Doesn't realize possession of weed is a Federal Felony in each and every state and territory in the USA.
>.gov
Maybe you should stop copypasting this in every thread and get some real source you lonely loser.
>Stoners too lazy to read
I guess you're right :(
I'm with Miley no more pot or coal for me
Stoners don't have the attention span to read.
You do realise they are indepedent studies that are hosted by that website and others?
What would you consider a "real source" ? A grasscity forum post? Lmao
WAAAAAAAAAAAH MOMMY GUBMINT MAKE THE STINKY POTHEAD GO AWAY WAAAAAAH ME NO LIKEY PARANOIA WAAAAAAA
>being THIS TRIGGERED by pot smoking
really lights my blunt my dude
if you dont smoke pot you should be shot on sight for being an autistic NEET faggot with no real friends that actually enjoy your company
Ok I'll read it. I just smoked for the first time probably in months if there's legit good reason not to I'll just quit.
Filthy potatofag in here whining about weed while half his country drinks themselves to sleep, top kek
I smoked for 6 years and quit 2 years ago my brain is still fugged from it :( I find it really hard to remember phone numbers and stuff now.
>everything your brain does is necessary at all times
Fuck your spooks.
I think you need to chillout and spark one bud, stressing over peoples minor lifestyle choices this much comes off the wrong way. Its almost neurotic.
its fun to do when your a teenager but if you continue to smoke pot after 21ish you are retarded
Alcohol is degenerate too. Why do weedfags constantly acccuse me of other unhealthy shit when I tell them weed is bad, that I don't do, that YOU do.
I don't drink. I bet you drink.
That's like what a girl would say when you tell her to stop sucking off groups of guys at the club if she wants people to respect her.
Something that don't use samples of few people or kids, don't use words like 'may, maybe, inconclusive' and are not posted on goverment site since Jews have great interest in keeping it illegal. You were btfo'd in that stupid amounts f threads you made before and still desperately cling to your shit, just don't smoke then. If you make it legal you make it more comfortable for me, if you make it illegal then I make free money.
I always win, baby.
OH THAT EXPLAINS IT! youre a retard with no common sense or self control so you smoked yourself retarded. probably held it in for 20 seconds after each hit. no wonder the irish anti-weed aspie hates it so much.
have fun with the brain damage goyim!
The studies with small sample sizes showed insignificant differences between controls, the studies with large sample sizes showed significant differences.
You can't just take the most inconclusive study in a meta analysis and say it represents the entire thing. Especially considering those inconclusive studies had results indicating YOU'RE right about this, not me.
And even if you do, if you stop, your body recovers in like a month.
Confirmed retard.
Did it also impair your ability to utilise critical thinking to discern between credible sources and '.gov' links?
>be op
>never got laid in high school
>browse Sup Forums
>make shit anti-weed thread
>"hurr durr people are idiots they don't live the life I do I'm obviously the master race weed fags btfo checkmate"
>jerks off vigorously alone with anime waifu while weed fags get laid
HI
And yet weed still reduces brain volume. Funny how my specific life circumstances have nothing to do with it, isnt it?
Recent studies have BTFO the "only heavy users" narrative, which was a sampling artefact of most prior studies only looking at such users. Smoking once a week is sufficient to cause structural change to the amygdala etc, just not as much as in a heavier user.
I still smoke "occasionally" anyway, but only due to a stoner friend. I should probably quit it entirely.
*citation needed*
>Doesn't realize that endogenous signaling can't penetrate a flood of plant-based THC and CBD, which render the neural ligands anandamide and 2-AG inoperative.
>Doesn't realise that weed wears off after a day.
Thanks OP. Was an interesting read.
But you're not right, just post 3 things that eat you enough to make you comfortable with infringing upon freedoms of people so that I can debunk them fast and we can move on things that actually matter, like actually getting high.
>Doesn't realise that your brain and body are still affected even if the high is gone
HOL UP. ALL YOU NIGGERS WAIT WHILE A GUY WHO ACTUALLY TOOK A GODDAMN COLLEGE LEVEL INTRO TO NEUROSCIENCE CLASS EXPLAINS.
YALLZ BRAIN CELLS USUALLY SEND SIGNALS ONE WAY WHEN NEUROTRANSMITTERS GET RELEASED FROM ONE CELL TO THE NEXT.
SOMETIMES THOSE NEUROTRANSMITTERS TELL THE NEXT CELL TO RAISE ITS FUCKING CALICUM LEVELS INSIDE. WE HAVE NO FUCKING CLUE WHAT SPECIFICALLY HAPPENS NEXT, BUT THAT CELL MAKES A BUNCH OF ENDOGENOUS CANNABINOIDS, WHICH ARE LIKE OIL AND CAN PASS THROUGH CELL MEMBRANES REALLY FUCKING EASILY. THOSE NEW MOLECULES GO BACKWARDS TO THE PREVIOUS NEURON AND MAKE IT DO A BUNCH OF SHIT.
Fuck off nigger do you know where you are?
Fucking normalfag
>you're not right I am
Okay
>be me
>be retarded
>come to Sup Forums
>read stories of former drug addicts that quit the stuff and got their life together
>Refuse to read government and university studies that show narcotics are harmful
>Make post about how Sup Forums never had friends in high school
>Refuse to go back to T_D
Don't really care.
I function at least 100x better than the sober fuckwits that surround me in my life. I'm impatient and quick to anger so I wouldn't get anything done without weed and I'd probably give myself a stroke if I tried to quit because there are too many sources of rage in my life.
this is why people hate nerds. I'm nerdy myself but I realized early that talking to people like they are stupid will get you nowhere.
>sleep
You spelled 'death' wrong
this, I still feel effects of smoking pot from like 2 years ago.
>i'm trying to read for 6 hours a day to compensate for my self-induced lobotomy
idk man something about what you're saying sounds like bullshit.
I feel pretty chilled out, not overpowered.
stay salty nerd. i took the redpill
SO NOW WEED HAS THC AND SHIT THAT ACTIVATES ALL THOSE FUCKIN RECEPTORS THAT ENDOGENOUS CANNABINOIDS ARE SUPPOSED TO WORK ON.
SO IT TURNS OUT THAT THOSE RECEPTORS DO A BUNCH OF SUBTLE SHIT LIKE MAKE MORE NEURONS, IMPROVE MEMORY, MAKE YOU FORGET IRRELEVANT BULLSHIT, KNOW WHEN TO EAT, INCREASE ATTENTION IN NEW SITUATIONS, RELAX WHEN IT'S ALL GOOD, REGULATION OF PAIN, REGULATION OF IMMUNE SYSTEM, AND A WHOLE FUCKLOAD OF STUFF THAT SMOKING WEED FUCKS WITH.
GOOD NEWS IS THAT MOST OF THAT SHIT GETS IMPROVED WITH THC, BUT WHAT HAPPENS WHEN YOU GO OFF IT AND YOUR BRAIN HAS TO COMPENSATE, OR WHEN YOUR BRAIN IS DEVELOPING AND GETS A WHOLE FUCKLOAD OF NEURON REMODELING.
It almost is but its not, because its weed and weed is harmless. Why dont you find something significant to obsess over, like a fucking career or something.
>endogenous signaling can't penetrate
That's the point you pseud. If endogenous signaling *could* override the exogenous chemical you're taking in then there would be no point in taking that chemical. Also:
>evolved to
>implying evolution has directed purpose
>THOSE NEW MOLECULES GO BACKWARDS TO THE PREVIOUS NEURON AND MAKE IT DO A BUNCH OF SHIT
OK, so what shit is that? Does it matter? Do things still work correctly when shit isn't going backwards?
Sounds like a protocol but my experience tells me that it's an unnecessary or even outdated one.
NORMIES GET OFF OUR BOARD REEEEEEEE
Protip: stoners are stupid.
Phytos and endos unlock the same things. They are the same keys. Look up "'failure to thrive' syndrome". If babby dont get endos and mamma dont have no phytos. Babby gon fucken die. Kys
proof that you weren't always retarded?
>A big one imo is stress response. In the beginning weed will help people with anxiety, but if they abuse it, it will end up contributing to super-anxiety
Happened to me.
For all drugs. Babby does worse. More deaths overall at birth. For weed? As in the mothers may or may not use any "drugs". SHE DOES BETTER THAN THE NO "DRUG" AT ALL WOMEN
I already posted like 38 studies showing how harmful it is >.>
You need to start replying to MY posts, drunken wife beating potato farmer
Used to lmao420blaze4dayz for a couple years. Went to 420 in Hyde park with some beers this year kind of expecting... fun. Wasn't any fun. Extremely bad, hostile, and stupid people.
Sweet. I loves me some paid anecdotes. Maybe everybody is shite then because most people get stoned in this country. Like you guys get drunk in the middle of walking the roads
Glad we found an agreement friend.
Degenerates need to get themselves sorted... Or we'll do it for them.
>a frog priestess some people call Old Ivan because he prolly a pedo
>lemme be your "father" little one
it definitly dulls your mind. Also people that start early like around 13 years old will never go back to being as sharp as they used to be. Not that its gone it just slows your thinking down a bit.
Common man has a right to travel on the public highway by any means, even if that means he is intoxicated. What you use to exemplar our degeneracy is one of the many pillars of English law and thus western civ.
>flag
By jove it checks out.
We don't live on a pear. And nukes aren't real. You never landed on the moon. And there is no way to determine the ages of rocks
>common law
>good
There's your problem. Roman Law ftfw
>not getting cosmic and listening to music for hours
>not contemplating life while in nature
>not becoming more spiritual and introspective
you're missing out
>needing weed to do those things
I feel sorry for you
>needing oxygen
Oxygen's bad. Oxygen turns nicotine into vitamin b3 and black lung is only for coal miners and lung cells regenerate every three weeks and this prevents preeclampsia
>but listen to me
No. This is new science. OP (your proxy), made a comment on a brand new science. Put your asshole away and go shit on something else. Filt communist
how high is this guy? I like pot just as much as the next guy. Its the only way I can relate to movies and tv and its literally the only way I can enjoy a videogame anymore. So there it is. Great for entertainment enjoyment but fucks everything else up.
You said i was dull. I am anything but dull
Communists are the ones smoking weed lmao. By far the vast majority of weed smokers are commies, and when you legalise weed people become more commie.
Also what the fuck are you talking about with Oxygen? What point are you trying to make?
>GOOD NEWS IS THAT MOST OF THAT SHIT GETS IMPROVED WITH THC, BUT WHAT HAPPENS WHEN YOU GO OFF IT AND YOUR BRAIN HAS TO COMPENSATE, OR WHEN YOUR BRAIN IS DEVELOPING AND GETS A WHOLE FUCKLOAD OF NEURON REMODELING.
Someone posted links to a number of peer-reviewed articles yesterday. Do any of those articles (or other articles) address the issues made in these remarks?
I.e.:
>MOST OF THAT SHIT GETS IMPROVED WITH THC
True dat?
>BUT WHAT HAPPENS WHEN YOU GO OFF IT AND YOUR BRAIN HAS TO COMPENSATE
Do we know?
>OR WHEN YOUR BRAIN IS DEVELOPING AND GETS A WHOLE FUCKLOAD OF NEURON REMODELING.
I assume this can't be good.