ITT: female main antagonists.
No antagonist henchwoman #147 (e.g. Lust from FMA) but the main antagonist (of the arc?), like Ragyo/Satsuki from KLK (Satsuki because she was the main antagonist for the 1st half) or Satella from Re:Zero.
Who's your favorite? Who do you hate? Do you like when the main antagonist is a woman?
Kongou from the Arpeggio anime
Nio but they're all girls in the show
Shinji's mom you know it's true
Kaguya from Naruto?
Dante from Fullmetal Alchemist. No one remembers Lyra, the original owner of the body.
Queen Beryl from Sailor Moon?
There really need to be more female antagonists.
Alphard from Canaan.
Satella
Pretty much all of Umineko.