Analyizing the effect of ASPM-A44871G-rev/T-rs41310927 and MCPH1-G37995C-rs930557, at first we find evidence of G being positively associated with cranial volume. This association collapses when GG and GC are divided;
>sciencedirect.com/science/article/pii/S1053811907004697
>Total brain volume =
>Highest = GG/AA(1559.5ml,) CC/GG(1562ml, GG/GG(1565.5ml)
>Average = GG/AA(1542ml,) CC/GG(1541ml,) GG/GG(1541.5ml)
>Lowest = GG/AA(1524.5ml,) CC/GG(1520ml,) GG/GG(1517.5ml)
>Meta-Average = GG/AA(1,542ml,) CC/GG(1,541ml,) GG/GG(1541.5ml)
>
>Cerebral cortical volume =
>Highest = GG/AA(732ml,) CC/GG(736.5ml,) GG/GG(734ml)
>Average = GG/AA(723ml,) CC/GG(725.5ml,) GG/GG(721.5ml)
>Lowest = GG/AA(714ml,) CC/GG(714.5ml,) GG/GG(709ml)
>Meta-Average = GG/AA(723ml,) CC/GG(725.5ml,) GG/GG(721.5ml)
>
>VI score =
>Highest = GG/AA(56.4,) CC/GG(55,) GG/GG(56.45)
>Average = GG/AA(50.35,) CC/GG(50.7,) GG/GG(50.95)
>Lowest = GG/AA(43.5,) CC/GG(46.4,) GG/GG(45.45)
>Meta-Average = GG/AA(50.083,) CC/GG(50.7,) GG/GG(50.95)
With GG and GC seperated and with GG assumed to be the microcephaly allele;
Cerebral cortical volume =
GG = 718.75mm-/+8.75, GC = 732.5ml-/+1.25, CC = 728ml-/+7,
Highest = GG/AA(726.75ml,) GC/GG(735.875ml,) CC/GG(736.6ml,) GG/GG(732.75ml)
Average = GG/AA(722.375ml,) GC/GG(727.75ml,) CC/GG(727.75ml,) GG/GG(720.875ml)
Lowest = GG/AA(714ml,) GC/GG(719.625ml,) CC/GG(714.5ml,) GG/GG(709ml)
Total brain volume =
GG = 1529.25 -/+5.25, GC = 1543-/+13.75, CC = 1542-/+13,
Highest = GG/AA(1545.75ml,) GC/GG(1562.875ml,) CC/GG(1562ml, GG/GG(1551.75ml)
Average = GG/AA(1535.125ml,) GC/GG(1541.5ml,) CC/GG(1541ml,) GG/GG(1534.625ml)
Lowest = GG/AA(1524.5ml,) GC/GG(1520.125ml,) CC/GG(1520ml,) GG/GG(1517.5ml)
Meta-average = GG/AA(1535.125ml,) GC/GG(1541.5ml,) CC/GG(1541ml,) GG/GG(1534.625ml)