Fully aware. Groups like the American Kratom Association are ramping into overdrive to see what can be done. I am not deluded to believe it will succeed but it is better to try. Not because I'll be sad that it all dries up for me, but the fact that it will do so likely indefinitely, with no further research, ever.
here is a break down of the currently known alkaloids in Kratom and the associative effects of each:
>Ajmalicine (Raubasine), a cerebrocirculant, antiaggregant, anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer
>Corynantheidine, an opioid antagonist
>Corynoxeine, a calcium channel blocker
>Corynoxine A and B, Dopamine mediating anti-locomotives
>Epicatechin, an antioxidant, antiaggregant, antibacterial, antidiabetic, antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant, antiviral, cancer preventative, alpha-amylase inhibitor
>9-Hydroxycorynantheidine, a partial opioid agonist
>7-Hydroxymitragynine, an analgesic, antitussive, antidiarrheal, primary psychoactive in kratom
>Isomitraphylline, an immunostimulant, anti-leukemic
>Isopteropodine, an immunostimulant
>Mitragynine, an analgesic, antitussive, antidiarrheal, adrenergic, antimalarial, possible psychedelic (5-HT2A) antagonist
>Mitraphylline, a vasodilator, antihypertensive, muscle relaxer, diuretic, anti-amnesic, possible immunostimulant
>Paynantheine, a smooth muscle relaxer
>Rhynchophylline, a vasodilator, antihypertensive, calcium channel blocker, antiaggregant, anti-inflammatory, antipyretic, anti-arrhythmic, antithelmintic
>Speciociliatine, a weak opioid agonist
>Speciogynine, a smooth muscle relaxer
>Speciophylline, an anti-leukemic; and Tetrahydroalstonine, a hypoglycemic, anti-adrenergic (at alpha-2)